Ana-Teresa Maia

Home of the Functional Genomics of Cancer group at University of Algarve

A large number of our genes are preferentially expressed from one allele due to regulatory polymorphisms occuring both in cis- and in trans-. This unequal expression contributes to susceptibility to common diseases, including cancer. Our main aim is to use this concept to develop new methods to study predisposition to breast cancer. Additionally, we investigate the role that this imbalance plays in tumour biology, namely in the effect of coding mutations and treatment response.